Fractionation and identification of ocular protective compounds from kochiae fructus against oxidative damage in retinal pigment epithelium cells
The protective effects of Kochiae Fructus against oxidative damage in RPE cell was validated with the KSEM fraction. The compound quercetin was identified as the important contributor. However, the synergistic effect of the hyperoside, quercetin, and kaempferol mixture may play a dominant role in the protective action of Kochiae Fructus. Overall, these findings highlight the potential of Kochiae Fructus and its flavonol mixture as a basis for developing treatments targeting ocular diseases associated with oxidative damage in retina.
Authors
- Yicheng Pan (ORCID: https://orcid.org/0000-0003-4918-3808)
- Ta‐Hsien Chuang
- Chia-Lin Lee (ORCID: https://orcid.org/0000-0002-5949-1989)
- Chih‐Hsin Tang (ORCID: https://orcid.org/0000-0002-7113-8352)
- Pei‐Yi Chu (ORCID: https://orcid.org/0000-0001-7336-2465)
- Yi‐Ting Lin (ORCID: https://orcid.org/0000-0003-3821-4744)
- Yang‐Chang Wu (ORCID: https://orcid.org/0000-0001-7815-2686)
- Jian‐Sheng Wu
- Wei-Yu Hsu
- Yingchun Yu
Institutions
- China Medical University (TW)
- China Medical University Hospital (TW)
- Changhua Christian Hospital (TW)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1016/j.jep.2025.119328
- Citations
- 1
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Ministry of Science and Technology, Taiwan
- China Medical University, Taiwan