Serum Exosomes miR-122-5P Induces Hepatic and Renal Injury in Septic Rats by Regulating TAK1/SIRT1 Pathway
Serum exosomal miR-122-5p promotes inflammation and induces liver/kidney injury in LPS-induced septic rats by modulating the TAK1/SIRT1/NF-κB pathway, highlighting potential therapeutic targets for sepsis management.
Authors
- Yujing Jiang
- Yamin Yuan (ORCID: https://orcid.org/0000-0001-9222-5992)
- Jinquan Zhou
- Liao Chen (ORCID: https://orcid.org/0000-0001-8294-6892)
- Xin Ma (ORCID: https://orcid.org/0000-0001-8525-068X)
- Yanfei Meng
- Ying Lv (ORCID: https://orcid.org/0000-0001-6448-5930)
- Jiaqi Wang (ORCID: https://orcid.org/0000-0002-1708-3573)
- Bei Zhang (ORCID: https://orcid.org/0000-0002-2361-5492)
- Li Ma (ORCID: https://orcid.org/0000-0002-2903-5704)
- Xiaorong Dong
- Jing Zhang (ORCID: https://orcid.org/0000-0002-4965-7076)
- T Z Li
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/idr.s499643
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Natural Science Foundation of Gansu Province