Astaxanthin-loaded PLGA nanoparticles inhibit survival of MKN-45 gastric cancer cell line by modulating JAK2/STAT3/mTOR/PI3K pathway
The encapsulation of ASX in PLGA nanoparticles enhances drug stability, enables targeted delivery, and allows for sustained release. This study highlights the therapeutic potential of ASX-loaded nanoparticles in targeting JAK2/STAT3/mTOR/PI3K pathways in GC treatment. Further research is needed to understand the mechanisms and clinical applications of this novel immunotherapy strategy.
Authors
- Seyed Mohammad Taghi Razavi Tousi (ORCID: https://orcid.org/0000-0002-0456-1142)
- M. Leila (ORCID: https://orcid.org/0000-0002-2133-5796)
- Mohammad Hossein YektaKooshali (ORCID: https://orcid.org/0000-0001-7339-8230)
- Masoud Hamidi (ORCID: https://orcid.org/0000-0003-3847-4247)
- Mahdieh SobhZahedi
Institutions
- Université Libre de Bruxelles (BE)
- Guilan University of Medical Sciences (IR)
- Islamic Azad University, Lahijan Branch (IR)
- Biotechnology Research Center (IR)
- University of Guilan (IR)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s12885-024-13401-4
- Citations
- 5
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.49
Funders
- Islamic Azad University
- Guilan University of Medical Sciences