Carbon-Ion Radiotherapy for Head and Neck Mucosal Melanoma: Preliminary Clinical Outcomes and the MedAustron Approach for Reporting RBE-Weighted Dose With 2 Models
Bi-RBE model (LEM-I, mMKM) optimized CIRT protocol improved dose comparability of plans between different systems. It also improved intratumoral LETd distribution and resulted in rapid tumor regression, favorable toxicity profile, and excellent early loco-regional control. It provides a promising alternative to surgery, though distant metastasis remains the key prognostic factor.
Authors
- Mansure Schafasand
- Carola Lütgendorf‐Caucig (ORCID: https://orcid.org/0000-0002-9860-5141)
- S. Tubin (ORCID: https://orcid.org/0000-0002-4543-5863)
- Piero Fossati (ORCID: https://orcid.org/0000-0001-9803-242X)
- Antonio Carlino (ORCID: https://orcid.org/0000-0002-2182-002X)
- Maciej Pelak (ORCID: https://orcid.org/0000-0001-9584-2996)
- Ankita Nachankar (ORCID: https://orcid.org/0000-0002-3742-8794)
- Markus Stock (ORCID: https://orcid.org/0000-0001-7510-7759)
- G. Martino
- Eugen B. Hug
Institutions
- Paracelsus Medical University (AT)
- Austrian Center for Medical Innovation and Technology (AT)
- Karl Landsteiner University of Health Sciences (AT)
- MedAustron (AT)
Publication Details
- Journal
- International Journal of Particle Therapy
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1016/j.ijpt.2025.100738
- Citations
- 1
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Karl Landsteiner Privatuniversität für Gesundheitswissenschaften