HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury
These findings illuminate the role of lactate-mediated HMGB1 lactylation in inducing AKI in mice through the activation of the HMGB1-NETs signaling pathway.
Authors
- Changchun Cao (ORCID: https://orcid.org/0000-0003-1992-4257)
- Qiang Zheng (ORCID: https://orcid.org/0009-0001-0850-0929)
- Xiaodong Liu (ORCID: https://orcid.org/0000-0002-7296-6520)
- Hao Ding (ORCID: https://orcid.org/0000-0002-5761-9280)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Mengqing Ma (ORCID: https://orcid.org/0000-0003-4402-7988)
- Yawen Cai (ORCID: https://orcid.org/0000-0002-7042-1594)
- Jiaxin Bao
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- The First People’s Hospital of Lianyungang (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fimmu.2024.1475543
- Citations
- 26
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 20.73
Funders
- Government of Jiangsu Province