Mitochondrial DNA oxidation and content in different metabolic phenotypes of women with polycystic ovary syndrome
This finding suggests that IR could be the main factor contributing to mitochondrial dysfunction in PCOS. Maintaining optimal mtDNA copies are crucial for mitochondrial and cell function, suggesting potential therapeutic targets for PCOS-associated metabolic disturbances.
Authors
- Mailén Rojo (ORCID: https://orcid.org/0009-0008-5336-9430)
- Giselle Adriana Abruzzese (ORCID: https://orcid.org/0000-0003-3498-7010)
- Gustavo Daniel Frechtel (ORCID: https://orcid.org/0000-0002-7287-8520)
- Hernán Pérez (ORCID: https://orcid.org/0000-0003-1352-9168)
- Gloria Edith Cerrone (ORCID: https://orcid.org/0000-0003-1217-8132)
- María Constanza Pautasso
- Andrea Liliana Millán (ORCID: https://orcid.org/0000-0002-5568-3254)
- Alicia Beatriz Motta (ORCID: https://orcid.org/0000-0002-8478-728X)
- Alejandra Duarte
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Buenos Aires (AR)
- Hospital de Clínicas "José de San Martín" (AR)
- Instituto Universitario de Ciencias de la Salud - Fundación Héctor A. Barceló (AR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fendo.2024.1501306
- Citations
- 5
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 8.49
Funders
- Universidad de Buenos Aires