Association of individual-based morphological brain network alterations with cognitive impairment in type 2 diabetes mellitus
This study demonstrated that patients with T2DM exhibit generalized cortical atrophy and damage to individual morphologic brain networks. It also identified overlapping and cognitively relevant key brain regions, primarily within the limbic/paralimbic network (especially the hippocampus and cingulate gyrus), which may serve as imaging markers for identifying cognitive deficits in T2DM. These findings offer new insights into the neural network mechanisms underlying T2DM-associated brain damage and cognitive impairment.
Authors
- Xuan Huang (ORCID: https://orcid.org/0000-0002-1116-0865)
- Weiye Lu (ORCID: https://orcid.org/0009-0002-6073-2281)
- Kun Wang (ORCID: https://orcid.org/0000-0001-9851-7080)
- Jiahe Wang (ORCID: https://orcid.org/0000-0002-7224-9716)
- Die Shen
- Shijun Qiu (ORCID: https://orcid.org/0000-0002-1840-0462)
- Ziyu Diao
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fneur.2024.1519397
- Citations
- 2
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China
- Guangzhou University