Dealing With Antibiotic Prophylaxis in Lung Transplantation in the Era of Multidrug Resistance: The Milano Algorithm

Infectious complications significantly impact morbidity and mortality following lung transplantation (LuTx), with over 25% of post-transplant deaths attributed to infections. Antibiotic prophylaxis during the surgical procedure is crucial for reducing early infections, though the current use of wide-spectrum antibiotics, especially in cases of multidrug-resistant organisms (MDROs), is contentious and varies widely across centre. This practice raises concerns about antimicrobial resistance (AMR), particularly in immunosuppressed patients requiring lifelong healthcare access. Syndromic multiplex polymerase chain reaction (mPCR) tests, which detect multiple pathogens simultaneously, have shown promise in quickly identifying pathogens and resistance mechanisms, thus enabling targeted treatments. However, their application in LuTx has been limited.

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Publication Details

Journal
Transplantation Proceedings
Published
2025-01-09
DOI
https://doi.org/10.1016/j.transproceed.2024.12.024
Citations
5
Primary Topic
Transplantation: Methods and Outcomes
Type
article
Field-Weighted Citation Impact
10.03
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article

Dealing With Antibiotic Prophylaxis in Lung Transplantation in the Era of Multidrug Resistance: The Milano Algorithm

Chiara Abbruzzese, Francesco Blasi, Giulia Renisi, Jacopo Fumagalli et al.
5 citations
Transplantation Proceedings
Transplantation: Methods and Outcomes
10.03
article

Dealing With Antibiotic Prophylaxis in Lung Transplantation in the Era of Multidrug Resistance: The Milano Algorithm

Chiara Abbruzzese, Francesco Blasi, Giulia Renisi, Jacopo Fumagalli, V. Rossetti, Letizia Corinna Morlacchi, A. Palleschi, Andrea Lombardi, Mario Nosotti, Lisa Cariani, Alessandra Bandera, Giacomo Grasselli, Davide Mangioni, Lorenzo Rosso, Annapaola Callegaro, Mauro Panigada
article en
5 citations

Abstract

Infectious complications significantly impact morbidity and mortality following lung transplantation (LuTx), with over 25% of post-transplant deaths attributed to infections. Antibiotic prophylaxis during the surgical procedure is crucial for reducing early infections, though the current use of wide-spectrum antibiotics, especially in cases of multidrug-resistant organisms (MDROs), is contentious and varies widely across centre. This practice raises concerns about antimicrobial resistance (AMR), particularly in immunosuppressed patients requiring lifelong healthcare access. Syndromic multiplex polymerase chain reaction (mPCR) tests, which detect multiple pathogens simultaneously, have shown promise in quickly identifying pathogens and resistance mechanisms, thus enabling targeted treatments. However, their application in LuTx has been limited.

Transplantation ProceedingsVol. 57(2)
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Ospedale Maggiore (IT)
Zero hunger
Openalex Percentile: Top 2%
Transplantation: Methods and Outcomes
10.03
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