Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways
Our research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. This cascade of events promotes OS progression by enhancing glycolytic metabolism and supplying energy for cancer cell growth, migration, and invasion. These findings suggest a potential therapeutic target and highlight the importance of understanding the regulatory network involving lncRNAs in cancer metabolism and progression.
Authors
- Keyue Ding (ORCID: https://orcid.org/0000-0002-3496-6415)
- Ning Yang (ORCID: https://orcid.org/0000-0001-5121-7208)
- Huiyao Gu
- Hailong Lun
- Chawnshang Chang (ORCID: https://orcid.org/0000-0001-8510-3516)
- Naiqiang Zhu (ORCID: https://orcid.org/0000-0002-9540-4408)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-3702-6541)
- Yanqi Liu (ORCID: https://orcid.org/0000-0003-3499-0201)
- Bin Chen (ORCID: https://orcid.org/0009-0000-9974-9430)
Institutions
- Chengde Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fonc.2024.1485605
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengde Medical University