Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients
The pharmacokinetics of imipenem in elderly patients were effectively characterized by the established PPK model, which includes creatinine clearance as a key covariate. This research will enhance our understanding of imipenem elimination and support precision dosing in this patient demographic.
Authors
- Xuemei Luo (ORCID: https://orcid.org/0000-0002-8292-6733)
- Huaijun Zhu (ORCID: https://orcid.org/0000-0002-3659-1282)
- Fang Qiu (ORCID: https://orcid.org/0000-0002-5673-3858)
- Jing Wang
- Lu Jin (ORCID: https://orcid.org/0000-0001-9716-6805)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fphar.2024.1524272
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39