ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway
Thus, ESAT-6 suppresses alloimmunity and inhibits allograft rejection by inducing CD4<sup>+</sup>Foxp3<sup>+</sup> Tregs through IĸBα/c-Rel signaling pathway.
Authors
- Zhenhua Dai (ORCID: https://orcid.org/0000-0002-6236-8105)
- Yuqun Zeng (ORCID: https://orcid.org/0000-0003-3402-1953)
- Feifei Qiu (ORCID: https://orcid.org/0000-0002-5073-2125)
- Yuchao Chen (ORCID: https://orcid.org/0009-0008-9676-7770)
- Huazhen Liu (ORCID: https://orcid.org/0000-0003-2311-6703)
- Jonathan S. Bromberg
- Jingru Lin (ORCID: https://orcid.org/0009-0001-9367-7672)
- Xiaofei Huang (ORCID: https://orcid.org/0009-0006-8611-8553)
- Chun-Ling Liang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- University of Maryland, Baltimore (US)
- Zhejiang Provincial People's Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fimmu.2024.1529226
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Bureau
- Zhejiang Traditional Chinese Medicine Administration