Mechanistic insights into HPV-positivity in non-smokers and HPV-negativity in smokers with head and neck cancer
The overexpression of SLPI caused by tobacco-smoking can hinder HPV cell entry by binding to AnxA2 and thus prevent successful HPV infection. Conversely, non-smokers have lower SLPI-levels, associated with an excess of unbound AnxA2, favoring HPV cell-entry. These findings support our hypothesis, suggesting a paradigm shift in understanding virus-related pathogenesis, particularly in the head and neck region, and the nature of HPV infection.
Authors
- Susanne S. Hille (ORCID: https://orcid.org/0000-0002-9809-4636)
- Markus Hoffmann (ORCID: https://orcid.org/0000-0003-4603-7696)
- Elgar Susanne Quabius
- Oliver Josef Müller (ORCID: https://orcid.org/0000-0001-8223-2638)
- Martin Laudien (ORCID: https://orcid.org/0000-0003-3342-3336)
- Susanne Wiegand (ORCID: https://orcid.org/0000-0003-1183-9226)
- Martin Müller (ORCID: https://orcid.org/0000-0002-0667-9574)
- Asita Fazel
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Schleswig-Holstein (DE)
- German Centre for Cardiovascular Research (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fonc.2024.1484319
- Citations
- 2
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.70