Electroacupuncture may protect pulmonary dysplasia in offspring with perinatal nicotine exposure by altering maternal gut microbiota and metabolites
These findings suggest that EA may exert its therapeutic effects on PNE-induced lung phenotype by altering maternal gut microbiota. The likely mechanism involves the associated improvement in serum SCFA levels in both mother and offspring, as well as the upregulation of SCFA receptors in the lung tissue of offspring.
Authors
- Yitian Liu (ORCID: https://orcid.org/0000-0001-8133-320X)
- Hewen Li
- Yana Xie (ORCID: https://orcid.org/0000-0001-8047-7295)
- Virender K. Rehan (ORCID: https://orcid.org/0000-0002-8948-8967)
- Fang Yang (ORCID: https://orcid.org/0000-0002-8393-6853)
- Tingting Guo (ORCID: https://orcid.org/0009-0007-4482-5564)
- Yifei Wang (ORCID: https://orcid.org/0000-0003-2813-1128)
- Ling Zhang (ORCID: https://orcid.org/0000-0002-1463-1458)
- Bo Ji (ORCID: https://orcid.org/0000-0001-5443-8698)
- Y. Quan (ORCID: https://orcid.org/0000-0002-1968-8250)
- Wu Le
- Reiko Sakurai
Institutions
- Beijing University of Chinese Medicine (CN)
- UCLA Medical Center (US)
- Harbor–UCLA Medical Center (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fmicb.2024.1465673
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tobacco-Related Disease Research Program
- National Natural Science Foundation of China