FeCl<sub>3</sub>‐Promoted Conjugate Reduction of Exocyclic α,β‐Unsaturated Ketones with Polymethylhydrosiloxane
Abstract A new iron catalytic conjugate reduction of exocyclic α,β‐unsaturated carbonyl compounds with PMHS has been established for the first time. The reaction utilized PMHS as readily available, non‐toxic, and mild reductant that can be handled in open air. This protocol exhibits high compatibility with various substituents, and gives excellent yields, providing an environmentally benign and efficient access to construct synthetically useful α‐benzyl cyclic ketone scaffolds.
Authors
- Yushuang Chen (ORCID: https://orcid.org/0000-0003-4157-8709)
- Bowen Hu (ORCID: https://orcid.org/0000-0001-9815-8938)
- Yulong Zhang
- Hang Wang (ORCID: https://orcid.org/0000-0002-3870-1879)
- Bin Gu (ORCID: https://orcid.org/0000-0002-5129-3507)
- Xiaoxue Tang (ORCID: https://orcid.org/0009-0006-4666-6782)
Institutions
- Chongqing Normal University (CN)
- Army Medical University (CN)
- Chongqing University of Science and Technology (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing University of Technology (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1002/ajoc.202400691
- Citations
- 2
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.07