Synergistic defecation effects of Bifidobacterium animalis subsp. lactis BL-99 and fructooligosaccharide by modulating gut microbiota
The results showed that BL-99, FOS, and BL-99+FOS each alleviated constipation, with the synbiotic showing significant efficacy in the first black stool defecation time, fecal number, fecal weight, and the gastrointestinal transit rate (<i>P</i> < 0.05). Additionally, significant increased in serum 5-HT and IL-10 were observed in the BL-99+FOS group, alongside an increased relative abundance of <i>Lachnospiraceae_NK4A136_group, Blautia</i>, and <i>Clostridium sensu stricto 1</i>, while significantly reducing the relative abundance of <i>Alistipes</i> and <i>Bacteroides</i>. These changes facilitated alterations in short-chain fatty acids (SCFAs) metabolism, and were closely associated with the expression of genes related to the 5-HT pathway and the modulation of serum inflammatory factors. This study provides a theoretical basis for BL-99 and FOS synbiotics to improve constipation by regulating the gut microbiota and metabolites.
Authors
- Xiaokang Niu (ORCID: https://orcid.org/0009-0000-7111-6105)
- Fuqing Wang (ORCID: https://orcid.org/0000-0002-0532-6347)
- Jianhua He (ORCID: https://orcid.org/0000-0002-9289-4405)
- Wen Zhao (ORCID: https://orcid.org/0000-0002-2530-7637)
- Shaoyang Ge (ORCID: https://orcid.org/0000-0001-6106-7004)
- Wei‐Lian Hung (ORCID: https://orcid.org/0000-0002-4223-170X)
- Shaoqi Shi (ORCID: https://orcid.org/0009-0007-1724-086X)
- Juan Chen (ORCID: https://orcid.org/0000-0002-5407-8239)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-1905-0468)
- Liwei Zhang (ORCID: https://orcid.org/0000-0002-0515-9841)
- Yicheng Wang (ORCID: https://orcid.org/0000-0002-8744-9972)
- Yixuan Li (ORCID: https://orcid.org/0000-0002-8000-3417)
- Ming Zhang (ORCID: https://orcid.org/0000-0003-1175-4636)
- Ran Wang (ORCID: https://orcid.org/0000-0002-8199-6895)
- Zhaozhong Zeng (ORCID: https://orcid.org/0009-0003-9987-5009)
- Jie Guo (ORCID: https://orcid.org/0000-0002-1259-3718)
- Qiuyue Jiang
- Bing Fang (ORCID: https://orcid.org/0000-0003-4818-9079)
- Jingjing He (ORCID: https://orcid.org/0000-0003-0322-4846)
- Jie Luo (ORCID: https://orcid.org/0000-0003-1495-8239)
Institutions
- Beijing Technology and Business University (CN)
- Tiandi Science & Technology (China) (CN)
- Inner Mongolia Yili Industrial Group (China) (CN)
- China Agricultural University (CN)
- Hunan Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fimmu.2024.1520296
- Citations
- 6
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 10.87