Circle-seq reveals that eccDNA may be a key blood biomarker for HBV-associated liver cancer
Our research results revealed the main characteristics of eccDNAs in the blood of patients with HBV-related HCC and LC. It was found that eccDNAs were mainly less than 1,000 bp in length. Difference analysis showed that some eccDNAs had consistent and overlapping expressions with mRNAs. We found that <i>LAMA4</i> <sup><i>[circle112550019-112550510</i>]</sup> and <i>KANK1</i> <sup><i>[circle674459-674907]</i></sup> are target genes related to HCC, and both of them may become potential biomarkers for the diagnosis and prognosis of HCC.
Authors
- Xiao fang Zhao
- Ran Xia (ORCID: https://orcid.org/0000-0001-6963-8836)
- Yan Tang
- Xu D. Liu (ORCID: https://orcid.org/0000-0003-4050-9939)
- Hua Pang (ORCID: https://orcid.org/0000-0001-6601-3208)
- Zhaoxia Wei
- T. Wu
- Rong Liu (ORCID: https://orcid.org/0009-0008-2084-4880)
Institutions
- Guangxi University (CN)
- The Fourth People's Hospital (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fgene.2024.1454153
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Guangxi University
- Division of Graduate Education