Distinct mRNA expression profiles and miRNA regulators of the PI3K/AKT/mTOR pathway in breast cancer: insights into tumor progression and therapeutic targets
Our findings suggest that the PI3K/AKT/mTOR pathway and its miRNA regulators play crucial roles in breast cancer progression, particularly in aggressive subtypes like TNBC. The identified miRNAs and mRNAs hold potential as biomarkers for diagnosis and treatment, but further validation in functional studies is required. This study provides a foundation for targeted therapies aimed at modulating this critical pathway to improve breast cancer outcomes.
Authors
- Olga Nowotny-Czupryna
- Kacper Boroń (ORCID: https://orcid.org/0000-0001-8207-5548)
- Beniamin Oskar Grabarek (ORCID: https://orcid.org/0000-0003-1633-7145)
- Nikola Zmarzły (ORCID: https://orcid.org/0000-0002-7833-6167)
- Dariusz Boroń (ORCID: https://orcid.org/0000-0002-2691-5829)
- Dominika Janiszewska-Bil (ORCID: https://orcid.org/0000-0002-9983-5272)
- Piotr Ossowski
- Tomasz Sirek
- Przemysław Borawski (ORCID: https://orcid.org/0000-0001-5128-454X)
- Katarzyna Król-Jatręga
- Elżbieta Mitka-Krysiak
Institutions
- Cuiavian University (PL)
- Academy of Fine Arts in Katowice (PL)
- WSB University (PL)
- University of Bielsko-Biała (PL)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fonc.2024.1515387
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.75