Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC
Collectively, our study proposes an R-loop scoring model associated with tumor immune microenvironment, lipid metabolism and prognostic value. CLTC, an R-loop regulator, emerges as a promising prognostic biomarker and therapeutic target, offering new insights into potential treatment strategies for HCC patients.
Authors
- Guowen Wang (ORCID: https://orcid.org/0000-0003-0945-7579)
- Xianfu Wei
- Jinyan Feng (ORCID: https://orcid.org/0000-0002-5334-5067)
- Yiqin Li (ORCID: https://orcid.org/0000-0001-8900-5198)
- Long Chen (ORCID: https://orcid.org/0000-0002-7347-3074)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-4119-7359)
- Chao Zhang (ORCID: https://orcid.org/0000-0001-7096-8488)
- Yao Xu (ORCID: https://orcid.org/0000-0003-4601-665X)
- Jianchao Liu (ORCID: https://orcid.org/0000-0001-5647-3518)
- Xiuxin Han (ORCID: https://orcid.org/0000-0001-6745-8794)
- Yongheng Liu (ORCID: https://orcid.org/0000-0003-4314-0065)
- Houzhi Yang
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fimmu.2024.1487372
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14