Gualou Guizhi Granule inhibits microglia-mediated neuroinflammation to protect against neuronal apoptosis in vitro and in vivo
Our findings reveal that GLGZG exerts its protective effects through the suppression of the Notch signaling pathway, thereby inhibiting microglia activation, reducing neuroinflammation, and safeguarding neurons from neuroinflammation-induced damage, offering potential as a therapeutic agent for ischemic stroke-induced neuroinflammation.
Authors
- Jinxuan Wang (ORCID: https://orcid.org/0000-0001-8137-5696)
- Lihong Nan
- Yuqin Zhang (ORCID: https://orcid.org/0000-0002-1449-6209)
- Han Huang (ORCID: https://orcid.org/0000-0002-9143-6453)
- Guohong Yan (ORCID: https://orcid.org/0000-0002-1978-9393)
- Yi Feng (ORCID: https://orcid.org/0000-0001-8021-7776)
- Xuezhen Li
- Yanan Li (ORCID: https://orcid.org/0000-0002-3862-7410)
- Yaping Chen (ORCID: https://orcid.org/0000-0001-6748-7448)
- Shuping Luo
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fimmu.2024.1527986
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Fujian University of Traditional Chinese Medicine