High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis
These findings demonstrate that integrin β1-plectin-F-actin axis is necessary for high matrix stiffness-driven migration of HCC cells, and provide evidence for the critical role of plectin in mechanotransduction in HCC cells.
Authors
- Qing Luo (ORCID: https://orcid.org/0000-0001-9329-0227)
- Zhihui Wang (ORCID: https://orcid.org/0000-0003-3098-5288)
- Guanbin Song (ORCID: https://orcid.org/0000-0001-5217-0296)
- Wenbin Wang
Institutions
- Chongqing University (CN)
- Ministry of Education (TH)
- Chongqing University of Technology (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s12915-025-02113-1
- Citations
- 12
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 13.82
Funders
- National Natural Science Foundation of China