Megastigmane glycoside and phenol glycosides from the bark of <i>Mallotus conspurcatus</i> Croizat

A new megastigmane glycoside, conspurcoside A (<b>1</b>), two new phenol glycosides, conspurcosides B (<b>2</b>) and C (<b>3</b>), along with twelve known compounds (<b>4 </b>-<b> 15</b>) were isolated from the bark of <i>Mallotus conspurcatus</i> Croizat. The structures of these compounds were identified through analysis of spectroscopic data, including 1D and 2D NMR, HRESIMS, and ECD methods. Compounds (<b>1 </b>-<b>6</b>, <b>14 </b>-<b> 15</b>) were tested for inhibition of NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells to investigate their anti-inflammatory effects. The results revealed that compounds <b>2</b> and <b>3</b> demonstrated moderate inhibitory effects on NO production with IC₅₀ values of 42.36 <i>μ</i>M and 44.81 <i>μ</i>M.