Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients

Our study did not find clear evidence of an increased RBE in parotid and submandibular glands with increasing LET<sub>d</sub>. On average an LET<sub>d</sub> effect was observed, however our sample size was too small to clearly define an RBE-LET relation. A larger cohort scanned at later time intervals could shed more light on this issue.

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Publication Details

Journal
Clinical and Translational Radiation Oncology
Published
2025-01-09
DOI
https://doi.org/10.1016/j.ctro.2024.100910
Primary Topic
Radiation Therapy and Dosimetry
Type
article
Field-Weighted Citation Impact
0.00

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article

Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients

Johannes A. Langendijk, Stefan Both, Wouter V. Vogel, Vineet Mohan et al.
Clinical and Translational Radiation Oncology
Radiation Therapy and Dosimetry
article

Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients

Johannes A. Langendijk, Stefan Both, Wouter V. Vogel, Vineet Mohan, R.J.H.M. Steenbakkers, Dirk Wagenaar
article en

Abstract

Our study did not find clear evidence of an increased RBE in parotid and submandibular glands with increasing LET<sub>d</sub>. On average an LET<sub>d</sub> effect was observed, however our sample size was too small to clearly define an RBE-LET relation. A larger cohort scanned at later time intervals could shed more light on this issue.

Clinical and Translational Radiation OncologyVol. 52
University Medical Center Groningen (NL), University of Groningen (NL), The Netherlands Cancer Institute (NL)
KWF Kankerbestrijding
Zero hunger
Openalex Percentile: Top 99%
Radiation Therapy and Dosimetry
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