The effect of ginsenoside Rg3 combined with doxorubicin on the proliferation of MHCC97-L liver cancer cells

Purpose: MHCC97-L liver cancer cells, as one of the common liver cancer cells, have 40% metastasis rate of lung cancer. As a commonly used and widely used drug for the treatment of various cancers on the market, doxorubicin has also shown significant effects in treating MHCC97-L cells in previous studies. Meanwhile, research has also shown that ginsenoside Rg3 can play a significant role in the treatment of MHCC97-L liver cancer cells. This study explores the therapeutic effect of the combination of ginsenoside Rg3 and doxorubicin on MHCC97-L liver cancer cells, in both vitro and vivo. Methods: The experiment will use MHCC97-L human liver cancer cell and xenograft mouse model. The cell proliferation is measured by using the CCK-8 detection method and the tumor inhibition rate of the drug in vivo experiments can be calculated formula. Possible results: There are 3 most possible results: (1)The combination of doxorubicin and ginsenoside Rg3 has stronger inhibitory effect than doxorubicin only on MHCC97-L cells, both in vitro and in vivo; (2) The combination of doxorubicin and ginsenoside Rg3 has a strong inhibitory effect in vitro experiments, but the effect is not significant in vivo experiments; (3) The combination of doxorubicin and ginsenoside Rg3 has similar inhibitory effect than doxorubicin only on MHCC97-L cells, both in vitro and in vivo. Conclusion: Our research results will provide important information for the clinical treatment of chemotherapy for lung cancer. Future research should focus on improving drug interactions in vivo and drug metabolism in vivo.