Analysis of mesenchymal stem cells in Alzheimers disease

The prevalence of Alzheimer's disease (AD) is increasing with the emerged of aging society. While there is no effective therapy to treat it, this review delves into the potential of mesenchymal stem cells (MSCs) in treating AD, a neurodegenerative disorder characterized by progressive memory loss and cognitive impairments. MSCs is a multipotent cell derived from various sources including bone marrow and adipose tissue, with low immunogenicity, ease of acquisition, and multifaceted therapeutic capabilities. MSCs can meliorate AD pathology in various aspects, including the reduction of amyloid- (A) plaques, enhancement of autophagy, and modulation of neuroinflammation. Therefore, this paper explores the use of mesenchymal stem cells (MSCs) in the clinical treatment of Alzheimer's disease based on a literature review, collating current research findings. Despite the promising preclinical outcomes, MSCs also need for further research and challenges related to effectiveness and the mechanism in human need to be further determine.