Pathogenesis and Treatments of Alzheimers Disease

Alzheimers Disease (AD) is a kind of neurodegenerative disease, and it usually occurs in senility. The number of people suffering from this disease is increasing every year, which makes AD become a major global public health problem. Once a person is diagnosed with AD, its really hard to heal. The early symptoms of AD include memory loss, difficulty with problem solving and planning, confusion about time and place and so on. The moderate symptoms include personality and behavioral changes, restlessness and wandering. The late stage symptoms include physical decline, severe memory loss, and increased vulnerability to infections. So, it's important to write a review paper about it. This paper presents Pathogenesis of AD including A hypothesis, Tau protein hypothesis, mitochondrial dysfunction, neuroinflammation hypothesis, cholinergic hypothesis and oxidative stress hypothesis. It also presents treatments of AD including RNAi therapeutics, ketogenic diet, probiotic interventions. Lastly, the paper suggests corresponding therapies for each pathogenesis.