High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy
A high concentration of TCA in HTR-8/SVneo cells decreased the expression of FTH1. Overexpression of FTH1 could prevent cell death from ferroptosis induced by TCA. Thus, inhibiting the downregulation of FTH1 could be a potential therapeutic target for ICP treatment.
Authors
- Wei Gu (ORCID: https://orcid.org/0000-0003-2566-1246)
- Mengru Sun
- Shi‐Yuan Cheng (ORCID: https://orcid.org/0000-0003-1737-0588)
- Weijian Zeng
- Mengnan Yang (ORCID: https://orcid.org/0009-0005-3050-1417)
- Yanyan Hou
- Yu Gu (ORCID: https://orcid.org/0000-0002-6090-578X)
- Huajing Yang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Shanghai Municipal People's Government (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s12884-025-07143-9
- Citations
- 6
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China