Prognostic factors in patients with localized and metastatic alveolar rhabdomyosarcoma. A report from two studies and two registries of the Cooperative Weichteilsarkom Studiengruppe <scp>CWS</scp>
PAX3::FOXO1 fusion should replace FOXO1 fusion as an adverse prognostic factor in risk stratification. The prognostic relevance of PAX7::FOXO1-positive and FOXO1 fusion negative aRMS, along with the clinical factors described in this report, allows further refinement of risk assessment of patients with localized and metastatic aRMS.
Authors
- Thomas Klingebiel (ORCID: https://orcid.org/0000-0001-5726-9092)
- Ruth Lydia Ladenstein (ORCID: https://orcid.org/0000-0001-6548-3873)
- Sabine Stegmaier (ORCID: https://orcid.org/0000-0001-7281-8811)
- Bernarda Kazanowska (ORCID: https://orcid.org/0000-0002-7198-9122)
- Claudia Blattmann (ORCID: https://orcid.org/0000-0003-4045-5838)
- Erika Hallmen (ORCID: https://orcid.org/0009-0008-2956-2804)
- Felix Niggli (ORCID: https://orcid.org/0000-0002-7553-3712)
- Gustaf Ljungman (ORCID: https://orcid.org/0000-0002-4949-2494)
- Monika Sparber‐Sauer (ORCID: https://orcid.org/0000-0001-9551-2399)
- Bernd Blank
- Ewa Kościelniak (ORCID: https://orcid.org/0000-0002-1519-7569)
- Christian Vokuhl (ORCID: https://orcid.org/0000-0002-4138-4536)
Institutions
- Goethe University Frankfurt (DE)
- Uppsala University (SE)
- University of Bonn (DE)
- University of Zurich (CH)
- University of Wrocław (PL)
- Olgahospital (DE)
- St Anna Children's Hospital (AT)
- University Hospital Frankfurt (DE)
- Klinikum Stuttgart (DE)
- Medical University of Vienna (AT)
- University of Tübingen (DE)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/cam4.70215
- Citations
- 6
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- Deutsche Krebshilfe
- Deutsche Kinderkrebsstiftung
- Förderkreis Krebskranke Kinder e.V. Stuttgart