The stereoselective bioactivity and mechanism of indoxacarb against <scp><i>Spodoptera frugiperda</i></scp>

Enantiomeric bioactivity of indoxacarb enantiomers against on S. frugiperda was observed. S-Indoxacarb demonstrated remarkable insecticidal efficacy. Upon ingestion by S. frugiperda, it induced oxidative damage. Furthermore, S-indoxacarb was metabolized to DCJW, which has a significant role in its insecticidal properties. The selective bioactivity of indoxacarb enantiomers in S. frugiperda might be attributed to the enantiomeric metabolites. These findings offer a new perspective on the selective mechanisms of chiral pesticides. © 2025 Society of Chemical Industry.