Role of TGF-β1/Smad3 signalling pathway in renal tubulointerstitial fibrosis and renal damage in elderly rats with isolated systolic hypertension induced by increased pulse pressure
Increased pulse pressure in elderly rats with ISH caused an increase in shear stress. These effects led to the development of EMT and the activation of its upstream TGF-β1/Smad3 signalling pathway, ultimately leading to renal tubular interstitial fibrosis causing renal injury.
Authors
- Anju Zhao (ORCID: https://orcid.org/0000-0002-7296-2300)
- Mengbi Cui
- Guiling Xia
- Xueying Wei (ORCID: https://orcid.org/0000-0002-5656-2892)
- Dong‐Hua Yang (ORCID: https://orcid.org/0000-0001-8649-5531)
- Lei Lei (ORCID: https://orcid.org/0000-0002-8211-7397)
- Lu Li (ORCID: https://orcid.org/0000-0002-2633-7942)
- Qiong Hu
- Qiaoling Tang
Institutions
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Acta cardiologica. Supplementum
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1080/00015385.2024.2445339
- Citations
- 4
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 5.72