Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control
Our data supports a new immunotherapeutic approach and a translational rationale to improve survival in PDAC.
Authors
- Jennifer P. Morton (ORCID: https://orcid.org/0000-0001-5766-9141)
- Alex Gordon‐Weeks (ORCID: https://orcid.org/0000-0003-2997-4194)
- Simei Go (ORCID: https://orcid.org/0000-0002-4793-1967)
- Mathias Tesson (ORCID: https://orcid.org/0009-0007-9755-717X)
- Alice C. Evans (ORCID: https://orcid.org/0000-0003-3109-4620)
- Frances Willenbrock (ORCID: https://orcid.org/0000-0001-6038-944X)
- Eric O’Neill (ORCID: https://orcid.org/0000-0002-0060-6278)
- Constantinos Demetriou
- Keaton Jones (ORCID: https://orcid.org/0000-0002-4765-2167)
- Tess A. Stanly (ORCID: https://orcid.org/0000-0003-3064-0925)
- Ahmet Hazini (ORCID: https://orcid.org/0000-0002-8552-2005)
- Giampiero Valenzano (ORCID: https://orcid.org/0009-0000-4882-4066)
- Shannon Nicole Russell
- Somnath Mukherjee (ORCID: https://orcid.org/0000-0002-2272-5569)
Institutions
- University of Oxford (GB)
- Cancer Research UK Scotland Institute (GB)
Publication Details
- Journal
- Gut
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1136/gutjnl-2024-333492
- Citations
- 12
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 9.57
Funders
- Cancer Research UK
- Academy of Medical Sciences
- Health Services Research Programme