Renal dysfunction after hematopoietic cell transplantation; a mini-review study

Bone marrow transplantation (BMT) can lead to renal manifestations, including acute kidney injury (AKI) and long-term renal dysfunction. Late-onset kidney disturbance can detect in around 20% of the BMT survivors. This condition is defined as bone marrow transplant nephropathy (BMTN). Total body irradiation is a main parameter in this syndrome, though concurrent or previous chemotherapies may aggravate the effect of radiation on the renal function and structure. BMT is characterized by inappropriate azotemia, anemia and hypertension while renal function may deteriorate acutely or more slowly. Other renal manifestations of BMT include hemolytic-uremia-like syndrome, which may manifest later (3-6 months or more), and membranous nephropathy, which is a rare complication of BMT.