Repurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and progenitor cells for transplantation
Augmenting the bone marrow reconstitution potential of HSPCs with treprostinil and cinacalcet shows promise for rescuing patients undergoing HCT. This approach is particularly beneficial for those patients at high risk of transplant failure due to limited numbers of available HSPCs. Furthermore, enhancing the potency of HSPCs has the potential to alleviate the burden and risks associated with HSPC donation, as it would reduce the number of cells needed for collection.
Authors
- Manuel Salzmann (ORCID: https://orcid.org/0000-0001-5477-3533)
- Günther Krumpl (ORCID: https://orcid.org/0000-0002-0587-9072)
- Madeleine Themanns
- Karoline Kollmann (ORCID: https://orcid.org/0000-0002-7937-4245)
- W. L. Strohmaíer (ORCID: https://orcid.org/0000-0001-8928-7105)
- Behnaz Afrashteh
- José Basílio (ORCID: https://orcid.org/0000-0001-7380-2942)
- Michael Freissmuth (ORCID: https://orcid.org/0000-0001-9398-1765)
- Michaela Prchal‐Murphy
- Eva Zebedin-Brandl (ORCID: https://orcid.org/0000-0001-8479-0158)
- Veronika Sexl (ORCID: https://orcid.org/0000-0001-9363-0412)
- Alex Farr (ORCID: https://orcid.org/0000-0002-4628-9052)
- Anita Pirabe
- Marlene Fischer (ORCID: https://orcid.org/0000-0001-5275-9252)
- Eva Maria Putz
- Julia Zehenter
Institutions
- University of Veterinary Medicine Vienna (AT)
- AOP Orphan (Austria) (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fphar.2024.1444311
- Citations
- 2
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 3.54
Funders
- AOP Orphan