Integrated Network Pharmacology and Transcriptomics Analysis to Elucidate the Mechanism of Huoxue Tongluo Qiwei Decoction in the Treatment of Erectile Dysfunction in Spontaneously Hypertensive Rats through Angii-Activated Pkcε Pathway
HTQD may activate the PKCε pathway through AngII, inhibit the expression of KCNE1 protein, relax vascular smooth muscles, and improve erectile function.
Authors
- Haisong Li (ORCID: https://orcid.org/0000-0002-6306-2570)
- Cong Zhao (ORCID: https://orcid.org/0000-0002-2354-425X)
- Jisheng Wang (ORCID: https://orcid.org/0000-0002-6973-2694)
- Junlong Feng (ORCID: https://orcid.org/0000-0001-6836-9793)
- Bin Wang (ORCID: https://orcid.org/0000-0001-7419-5080)
- Kun Zou (ORCID: https://orcid.org/0000-0001-5182-6855)
- Sheng Deng (ORCID: https://orcid.org/0000-0003-0073-5579)
Institutions
- Beijing University of Chinese Medicine (CN)
- Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-01-09
- DOI
- https://doi.org/10.2174/0113862073330086241016115236
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00