Unravelling sources of variability on rocuronium pharmacokinetics: Implications for prolonged recovery in older patients
Our findings suggest that older patients take slightly longer to recover than younger adults due to an age-dependent increase in tissue uptake. However, a priori dose adjustments for rocuronium in older patients are not feasible, since age contribution is overshadowed by the overall variability in the recovery time.
Authors
- Valvanera Vozmediano (ORCID: https://orcid.org/0000-0002-2636-1889)
- Anthony Gebhart (ORCID: https://orcid.org/0000-0003-0635-147X)
- Leandro Francisco Pippa (ORCID: https://orcid.org/0000-0002-2782-0389)
- Günther Weindl (ORCID: https://orcid.org/0000-0002-4493-7597)
- Francine Johansson Azeredo (ORCID: https://orcid.org/0000-0003-3625-0186)
- Gabriela Rocha Lauretti (ORCID: https://orcid.org/0000-0003-3691-8289)
- Natália Valadares de Moraes (ORCID: https://orcid.org/0000-0002-4389-058X)
- Stephan Schmidt
- Miriam S. R. Happ
Institutions
- Universidade de Ribeirão Preto (BR)
- University of Bonn (DE)
- Universidade de São Paulo (BR)
- University of Florida (US)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1111/bcp.16386
- Citations
- 1
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 2.19
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo