Mapping Nanoscale‐To‐Single‐Cell Phosphoproteomic Landscape by Chip‐DIA (Adv. Sci. 1/2025)
Single‐Cell Phosphoproteomic Analysis In article 2402421, Hsiung‐Lin Tu, Yu‐Ju Chen, and co‐workers present a novel phosphoproteomic chip combined with mass spectrometry to map the phosphoproteomic landscape at single‐cell resolution. This cover artwork highlights the chip, symbolized as a ‘vessel’ that navigates through single‐cell capture, lysis, protein digestion, and phospho‐enrichment, revealing the first phosphoprotein network that drives cellular signaling within a single cell. [Image: see text]
Authors
- Sung‐Liang Yu (ORCID: https://orcid.org/0000-0003-4535-9036)
- Fengchao Yu (ORCID: https://orcid.org/0000-0002-7695-3698)
- Gul Muneer (ORCID: https://orcid.org/0000-0001-9397-5736)
- Hsiung‐Lin Tu (ORCID: https://orcid.org/0000-0003-1125-1879)
- Yu‐Ju Chen (ORCID: https://orcid.org/0000-0002-3178-6697)
- Sofani Tafesse Gebreyesus (ORCID: https://orcid.org/0000-0002-2595-1799)
- Cheng‐An J. Lin (ORCID: https://orcid.org/0000-0002-0452-1132)
- Min‐Shu Hsieh (ORCID: https://orcid.org/0000-0002-0594-3732)
- T D Lee
- Chao‐Chi Ho
- Alexey I. Nesvizhskii (ORCID: https://orcid.org/0000-0002-2806-7819)
- Ciao‐Syuan Chen
Publication Details
- Journal
- Advanced Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/advs.202570004
- Primary Topic
- Advanced Biosensing Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00