Prognostic Features and Potential for Immune Therapy in Metastatic Mismatch Repair‐Deficient Colorectal Cancer: A Retrospective Analysis of a Large Consecutive Population‐Based Patient Series
As dMMR CRC patients are generally older, with often significant comorbidities, only a limited portion of patients with metastatic dMMR tumors ended up in oncological treatments. Many of the metastatic tumors presented features that may impair response to PD-1 blockade therapy.
Authors
- Maarit Ahtiainen (ORCID: https://orcid.org/0000-0002-3263-2307)
- Hanna Elomaa (ORCID: https://orcid.org/0000-0002-5378-7703)
- Marja Hyöty
- Jan Böhm (ORCID: https://orcid.org/0000-0001-9664-588X)
- Erkki‐Ville Wirta (ORCID: https://orcid.org/0000-0002-2255-6136)
- Toni T. Seppälä (ORCID: https://orcid.org/0000-0002-4940-3498)
- Jukka‐Pekka Mecklin (ORCID: https://orcid.org/0000-0003-4895-2249)
- Juha P. Väyrynen (ORCID: https://orcid.org/0000-0002-8683-2996)
Institutions
- University of Helsinki (FI)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Central Finland Health Care District (FI)
- University of Jyväskylä (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/cam4.70555
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Ida Montinin Säätiö
- Suomen Lääketieteen Säätiö
- Mary och Georg C. Ehrnrooths Stiftelse
- Academy of Finland
- Jane ja Aatos Erkon Säätiö
- Emil Aaltosen Säätiö
- Sigrid Juséliuksen Säätiö
- Syöpäsäätiö
- Relander Foundation