LcProt: Proteomics‐based identification of plasma biomarkers for lung cancer multievent, a multicentre study
Our study developed an innovative nanomaterial, Zeolite NaY, which addressed the masking effect and improved the depth of the proteome. The performance of NaY-based plasma proteomics as a preclinical diagnostic tool was validated through both internal and external cohort. Furthermore, we explored the different patterns of plasma protein changes during the progression of lung cancer and used the explanations method to elucidate the roles of proteins in the multitask predictive model.
Authors
- Zhiming Ye (ORCID: https://orcid.org/0009-0009-9389-8182)
- Jie Li (ORCID: https://orcid.org/0000-0002-6873-6159)
- Xin Xu (ORCID: https://orcid.org/0000-0002-9485-8782)
- Hengrui Liang (ORCID: https://orcid.org/0000-0002-1155-5963)
- Yu Jiang (ORCID: https://orcid.org/0000-0001-7344-7274)
- Ran Cheng (ORCID: https://orcid.org/0000-0002-7617-3018)
- Wenhua Liang (ORCID: https://orcid.org/0000-0002-1391-8238)
- Jianqi Zheng (ORCID: https://orcid.org/0000-0002-7545-6323)
- Wang‐Zhong Li (ORCID: https://orcid.org/0000-0002-2744-8775)
- Lei Song (ORCID: https://orcid.org/0000-0001-5863-2658)
- Zhanpeng Jiang
- Ying Huang (ORCID: https://orcid.org/0000-0003-1145-3606)
- Jianxing He (ORCID: https://orcid.org/0000-0003-1737-8192)
- Runchen Wang (ORCID: https://orcid.org/0000-0003-1969-7859)
- Xiaohong Zhao (ORCID: https://orcid.org/0000-0003-3659-4800)
- Na Zhao (ORCID: https://orcid.org/0009-0003-7045-936X)
- Yan Yun
- Yuechun Lin (ORCID: https://orcid.org/0009-0004-8855-8355)
- Hongsheng Deng
- Jun Liu (ORCID: https://orcid.org/0000-0001-6766-5611)
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Tianjin Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/ctm2.70160
- Citations
- 8
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 6.05
Funders
- State Key Laboratory of Respiratory Disease
- National Natural Science Foundation of China
- National Key Research and Development Program of China