Prospects for Utilizing Codiaeum variegatum L. Leaf Extract to Inhibit Propionibacterium acnes and Bacillus subtilis Growth

Abstract Codiaeum variegatum L plant is medicinal plant, this plant can produce antibacterial secondary metabolites, namely: alkaloids, flavonoids, tannins, and steroids. The research is done to: examine the antibacteria effect of C. variegatum leaves ethanol extract with various concentrations against the growth inhibition of P. acnes ; examine the antibacteria effect of C. variegatum leaves ethanol extract with various concentrations against the growth inhibition of B. subtilis ; determine the most effective concentration of C. variegatum leaves ethanol extract to inhibit P. acnes growth; and determine the most effective concentration of C. variegatum leaves ethanol extract to inhibit B. subtilis growth. Extraction using maceration method. The antibacteria effect determination of C. variegatum leaf extract used the agar well diffusion method, each well was filled with bacteria liquid culture and incubated at 37 °C for 1 × 24 hours. The research results are there is antibacteria effect of ethanol extract C. variegatum leaves to inhibit P. acnes and B. subtilis growth; the most effective concentration of C. variegatum ethanol extract leaves to inhibit the growth of P. acnes is 90%, while the most effective concentration in inhibit B. subtilis is 100%.