Massively Parallel Screening of Toll/Interleukin‐1 Receptor (TIR)‐Derived Peptides Reveals Multiple Toll‐Like Receptors (TLRs)‐Targeting Immunomodulatory Peptides (Adv. Sci. 1/2025)

Toll‐Like Receptors In article 2406018, Keunwan Park, Wook‐Bin Lee, Moon‐Hyeong Seo, and co‐workers present an unprecedented peptide screening method that systematically explores TIR‐TIR interactions through a massive library of over 190,000 peptides. The discovered peptides effectively modulate TLR‐mediated inflammatory responses and, notably, show therapeutic potential as topical eye drops for age‐related macular degeneration, highlighting a promising direction for ophthalmic drug development. [Image: see text]