Investigation of the Protective Effects of Dexmedetomidine, Midazolam, Propofol, and Intralipid on Oxidative Stress and Inflammation in Rats with Lidocaine-Induced Toxicity
It was observed that pretreatment with midazolam increased oxidative stress induced by lidocaine, while dexmedetomidine and intralipid exhibited greater antioxidant effects. Dexmedetomidine and intralipid used as pretreatment were shown to be more effective in protecting against oxidative stress and inflammation.
Authors
- Merve Kacan
- Selman Aktaş (ORCID: https://orcid.org/0000-0002-8493-5000)
- Cumaali Demirtaş (ORCID: https://orcid.org/0000-0001-5226-6730)
- Hakan Beyaztaş (ORCID: https://orcid.org/0000-0003-3706-5193)
- Eray Metin Güler (ORCID: https://orcid.org/0000-0003-4351-1719)
- Mehmet Yıldırım (ORCID: https://orcid.org/0000-0003-1798-5478)
- Ayten Saraçoğlu (ORCID: https://orcid.org/0000-0002-1186-0933)
- Paweł Ratajczyk (ORCID: https://orcid.org/0000-0001-7136-2568)
- Tomasz Gaszyński (ORCID: https://orcid.org/0000-0001-5250-3978)
- Kemal Tolga Saraçoğlu (ORCID: https://orcid.org/0000-0001-9470-7418)
- Ferda Serdoğan (ORCID: https://orcid.org/0000-0002-9515-017X)
- Mustafa Kucun (ORCID: https://orcid.org/0009-0009-1022-7317)
Institutions
- Bartin University (TR)
- Hamad General Hospital (QA)
- Sivas State Hospital (TR)
- Medical University of Lodz (PL)
- Haydarpaşa Numune Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Kocaeli Üniversitesi (TR)
- Istanbul University (TR)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/jir.s493566
- Citations
- 3
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 3.96