Plasma Concentrations of Benzylpenicillin and Cloxacillin in Infective Endocarditis—With Special Reference to Delayed Hypersensitivity Reactions
This study revealed significant interindividual variation in plasma concentrations for both studied penicillins. TDM might be useful in situations where concentrations are hard to predict, such as severe obesity or kidney failure. Additionally, we found no indication that high plasma concentrations are related to the prevalence of DHR.
Authors
- Lars Olaison
- Birgitta Larsson (ORCID: https://orcid.org/0000-0001-5160-8882)
- Ulrika Snygg‐Martin (ORCID: https://orcid.org/0000-0001-7985-8277)
- Maria Hägglund (ORCID: https://orcid.org/0000-0002-6839-3651)
- Magnus Brink
- Michael Stofkoper
Institutions
- Sahlgrenska University Hospital (SE)
- Region Västra Götaland (SE)
- Södra Älvsborg Hospital (SE)
- Norra Älvsborgs Länssjukhus (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3390/antibiotics14010056
- Primary Topic
- Infective Endocarditis Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Västra Götalandsregionen