The Screening Tomosynthesis Trial with Advanced Reader Methods (STREAM): design and rationale of a population-based breast cancer screening trial
Question The short-, medium-, and long-term effects of digital breast tomosynthesis (DBT) imaging in the Dutch breast cancer screening programme are unknown, but essential to decide about implementation. Findings This protocol paper describes the primary endpoint of the STREAM trial: the combined interval and advanced cancer detection rate at the second DBT round. Clinical relevance The STREAM trial is a prospective, non-randomised, population-based study in the Dutch breast cancer screening programme, that aims to evaluate the effects and acceptability of two rounds of DBT screening to determine if DBT can enhance the programme's outcomes.
Authors
- Nehmat Houssami (ORCID: https://orcid.org/0000-0002-3641-952X)
- Adriana M. J. Bluekens
- Lindy M. Kregting (ORCID: https://orcid.org/0000-0002-8262-0080)
- Ruud M. Pijnappel (ORCID: https://orcid.org/0000-0002-6912-9414)
- Lian J. Pennings (ORCID: https://orcid.org/0000-0003-3343-6823)
- Ellen Verschuur
- Mireille J. M. Broeders (ORCID: https://orcid.org/0000-0002-8741-8148)
- Lisa Dunning
- Hans ‘t Mannetje
- Ruben E. van Engen (ORCID: https://orcid.org/0000-0001-7006-1376)
- Maartje Smid-Geirnaerdt
- Nicolien T. van Ravesteyn (ORCID: https://orcid.org/0000-0003-3531-466X)
- Ioannis Sechopoulos (ORCID: https://orcid.org/0000-0001-9615-8205)
- Marja van Oirsouw
- Cary van Landsveld-Verhoeven
- Daan van den Oever
Institutions
- The University of Sydney (AU)
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Borstkankervereniging Nederland (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Dutch Expert Centre for Screening (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- University of Twente (NL)
- Cancer Council NSW (AU)
Publication Details
- Journal
- European Radiology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1007/s00330-024-11324-z
- Citations
- 4
- Primary Topic
- Digital Radiography and Breast Imaging
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- ZonMw
- KWF Kankerbestrijding