Enhanced Costimulation Blockade With αCD154, αCD2, and αCD28 to Promote Heart Allograft Tolerance in Nonhuman Primates
Intensive costimulation pathway blockade with αCD2, αCD154, and αCD28 promotes lymphocyte chimerism at the cost of high incidence of posttransplantation lymphoproliferative disease and opportunistic infections, preventing assessment of the effectiveness of the regimen to promote alloimmune tolerance.
Authors
- Victor Tkachev (ORCID: https://orcid.org/0000-0001-6011-0576)
- Ivy A. Rosales (ORCID: https://orcid.org/0000-0003-0621-3202)
- Seth Lederman (ORCID: https://orcid.org/0000-0003-2781-1455)
- Ryan Chaban (ORCID: https://orcid.org/0000-0002-0484-8362)
- Madelyn Ma (ORCID: https://orcid.org/0000-0002-4882-2885)
- Kohei Kinoshita (ORCID: https://orcid.org/0009-0004-3267-906X)
- Zahra Habibabady (ORCID: https://orcid.org/0000-0002-3314-3716)
- Richard N. Pierson (ORCID: https://orcid.org/0000-0003-3764-4590)
- Akihiro Maenaka (ORCID: https://orcid.org/0000-0002-6216-4890)
- Joren C. Madsen (ORCID: https://orcid.org/0000-0003-2724-1333)
- Gannon McGrath (ORCID: https://orcid.org/0000-0003-1642-4273)
- Ikechukwu Ileka
- Victoria Diaz
Institutions
- Harvard University (US)
- Johannes Gutenberg University Mainz (DE)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Transplantation
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1097/tp.0000000000005315
- Citations
- 4
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 8.03