SNHG16 alleviates pulmonary ischemia-reperfusion injury by promoting the Warburg effect through regulating MTCH2 expression: experimental studies
Our findings revealed that SNHG16 overexpression suppressed OGD/R-induced HPMEC apoptosis by promoting Warburg effect, and HPMEC-derived exosomal SNHG16 alleviated PIRI through the miR-372-3p/miR-373-3p/MTCH2 axis, suggesting that SNHG16 as a therapeutic target for PIRI.
Authors
- Meng Shi (ORCID: https://orcid.org/0000-0002-5412-7977)
- Mengkun Shi
- Meng Xiang (ORCID: https://orcid.org/0000-0002-3870-5191)
- Qi Shi (ORCID: https://orcid.org/0000-0001-6530-0264)
- Kun Gao (ORCID: https://orcid.org/0000-0001-9060-3881)
- Wenyong Zhou (ORCID: https://orcid.org/0000-0001-9261-025X)
- Nana Feng (ORCID: https://orcid.org/0000-0002-6851-6324)
- Wan Posum
- Shaohua Wang (ORCID: https://orcid.org/0009-0007-7701-7889)
- Jichun Yang (ORCID: https://orcid.org/0000-0002-6202-5241)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Chest Hospital (CN)
- Shanghai Eighth People Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1097/js9.0000000000002217
- Citations
- 5
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 4.68