Mining functional gene modules by multi-view NMF of phenome-genome association
Utilizing the information in the hierarchical structure of phenotype ontology, CMNMF can identify functional gene modules with more biological significance than conventional methods. CMNMF can also be a better tool for predicting members of gene pathways and protein-protein interactions.
Authors
- YaoGong Zhang
- MaoQiang Xie
- Wenqian He (ORCID: https://orcid.org/0000-0002-7618-8228)
- Ling Ma (ORCID: https://orcid.org/0000-0002-4352-5697)
- Lin Wang (ORCID: https://orcid.org/0000-0002-3889-5714)
- Mingming Liu (ORCID: https://orcid.org/0000-0002-6861-5824)
- Yalou Huang (ORCID: https://orcid.org/0000-0002-6573-1854)
- Jin Xu (ORCID: https://orcid.org/0000-0001-5111-1286)
- YingJie Xu
Institutions
- Nankai University (CN)
- Tianjin International Joint Academy of Biomedicine (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s12864-024-11120-5
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Tianjin City