Late-life physical activity, midlife-to-late-life activity patterns, APOE ε4 genotype, and cognitive impairment among Chinese older adults: a population-based observational study
Our findings underscore the multifaceted benefits of PA in mitigating cognitive impairment risk among older Chinese adults. Public health strategies should focus on promoting overall late-life PA levels, especially moderate-intensity PA, and maintaining activity levels comparable to midlife, with potential for personalized interventions based on genetic risk profiles.
Authors
- Mengyu Fan (ORCID: https://orcid.org/0000-0002-6452-3383)
- Ben Zhang (ORCID: https://orcid.org/0009-0008-6639-4731)
- Xunying Zhao (ORCID: https://orcid.org/0000-0002-6754-9773)
- Xueyao Wu (ORCID: https://orcid.org/0000-0001-6856-0520)
- Tianpei Ma (ORCID: https://orcid.org/0000-0002-4510-9697)
- Jiaqiang Liao (ORCID: https://orcid.org/0000-0002-3402-3011)
- Xin Chen (ORCID: https://orcid.org/0000-0002-8980-7032)
- Tao Zhang (ORCID: https://orcid.org/0000-0001-7279-8929)
- Li Zhang (ORCID: https://orcid.org/0000-0002-3087-7490)
- Jinyu Xiao (ORCID: https://orcid.org/0000-0003-2318-313X)
- Jiayuan Li (ORCID: https://orcid.org/0000-0002-2920-1637)
- Mingshuang Tang
- Xia Jiang
Institutions
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- Karolinska Institutet (SE)
- West China Hospital of Sichuan University (CN)
- Hainan General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- International Journal of Behavioral Nutrition and Physical Activity
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s12966-024-01691-7
- Citations
- 9
- Primary Topic
- Physical Activity and Health
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- Science Fund for Creative Research Groups
- Key Technologies Research and Development Program