Characteristics, risk factors and a risk prediction model of tocilizumab-induced hypofibrinogenemia: a retrospective real-world study of inpatients
The infection, COVID-19, CAR-T therapy, and concomitant glucocorticoids were independent risk factors for T-HFIB, while high baseline fibrinogen and concomitant antirheumatic drugs were protective factors. This nomogram can help early identify the patients at potential high risk of developing T-HFIB.
Authors
- Le Cai (ORCID: https://orcid.org/0000-0002-0656-2691)
- Zihan Qiu
- Xiao‐Yan Wen (ORCID: https://orcid.org/0000-0001-6728-0025)
- An Fu (ORCID: https://orcid.org/0000-0002-7532-0856)
- Man Zhu (ORCID: https://orcid.org/0000-0003-0627-2800)
- Dai-Hong Guo (ORCID: https://orcid.org/0000-0002-5839-1492)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s40360-024-00827-6
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 4.18