<i>KCNJ5</i> Somatic Mutations Are Associated With Better Long-term Outcomes in Patients With Unilateral Primary Aldosteronism
Patients with uPA harboring KCNJ5 somatic mutations had a lower risk of long-term MACCEs and mortality following adrenalectomy. These patients were more likely to achieve complete clinical success, which contributed to improved outcomes. However, the benefits were influenced by factors such as baseline potassium levels, hypertension duration, BMI, eGFR, and residual hypertension, highlighting the interplay of genetic and clinical factors in determining prognosis.
Authors
- Chin‐Chen Chang (ORCID: https://orcid.org/0000-0002-0121-4866)
- Chieh‐Kai Chan (ORCID: https://orcid.org/0000-0003-4529-3161)
- Yen‐Hung Lin (ORCID: https://orcid.org/0000-0001-8153-1441)
- Vin‐Cent Wu (ORCID: https://orcid.org/0000-0001-7935-0991)
- Wei‐Shiung Yang (ORCID: https://orcid.org/0000-0001-5087-373X)
- Shih‐Chieh Chueh (ORCID: https://orcid.org/0000-0002-0713-4904)
Institutions
- Aletheia University (TW)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- National Taipei University (TW)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1210/clinem/dgaf007
- Citations
- 7
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 9.06