β-Thioamide Sulfone Enabled Copper-Catalyzed Ring-Opening/Sulfonylation of Cyclopropenes: Access to Alkyl Aryl Sulfones
Sulfone motifs play important roles in bioactive compounds and functional materials. The development of efficient methodologies for constructing sulfonyl-containing compounds has thus attracted considerable attention. Here, we introduce a protocol for the preparation of alkyl aryl sulfones under mild conditions. This protocol employs β-thioamide sulfone as a novel sulfone motif donor. It forms sulfinates in situ under basic conditions, which then undergo cross-coupling with the intermediates that were generated from ligand-free copper-catalyzed cyclopropenes (CPEs) ring opening.
Authors
- Yi Kong (ORCID: https://orcid.org/0000-0002-2329-7009)
- C.‐S. CHUNG (ORCID: https://orcid.org/0000-0002-0233-1511)
- Qin Yin (ORCID: https://orcid.org/0000-0003-3534-3786)
- Yidong Liu (ORCID: https://orcid.org/0000-0002-7988-8908)
- Jingru Wang (ORCID: https://orcid.org/0000-0001-6310-8885)
- Cheng‐Xiang Wang (ORCID: https://orcid.org/0000-0002-9729-9592)
- Shaoquan Lin (ORCID: https://orcid.org/0000-0001-9132-4817)
- Arshad Ali
- Lang Liu (ORCID: https://orcid.org/0009-0007-8868-701X)
Institutions
- Chongqing University (CN)
- Shenzhen University (CN)
- Chinese Academy of Sciences (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Shenzhen Technology University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1021/acs.orglett.4c04352
- Citations
- 4
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province