Electrophysiological Signatures of Alpha Coma
Alpha-coma shows increased aperiodic activity and EEG complexity, despite similar alpha power and clustering coefficient. The increased aperiodic activity aligns with findings in other comatose patients, including those sedated or with subcortical dysfunction. However, the increased entropy contradicts existing literature, suggesting that alpha-coma may represent a state of widespread cortical dysfunction likely resulting from nonhierarchical, turbulent brain activity. This indicates that the loss of consciousness does not guarantee consistent cortical measures across the whole spectrum of EEG patterns.
Authors
- Hervé Quintard (ORCID: https://orcid.org/0000-0002-3870-6370)
- Francesco Misirocchi (ORCID: https://orcid.org/0000-0001-8730-4397)
- Pia De Stefano (ORCID: https://orcid.org/0000-0002-7979-0994)
- Isotta Rigoni (ORCID: https://orcid.org/0000-0002-5804-2137)
- Margitta Seeck (ORCID: https://orcid.org/0000-0002-6702-0167)
- Serge Vulliémoz (ORCID: https://orcid.org/0000-0002-1877-8625)
- Giulio Degano (ORCID: https://orcid.org/0000-0003-1540-780X)
- Andreas Kleinschmidt (ORCID: https://orcid.org/0000-0002-8094-0830)
- Peter W. Kaplan (ORCID: https://orcid.org/0000-0003-0578-7220)
- Karl Schaller (ORCID: https://orcid.org/0009-0001-8477-5553)
Institutions
- University of Geneva (CH)
- University of Parma (IT)
- Johns Hopkins University (US)
- Johns Hopkins Bayview Medical Center (US)
- University Hospital of Geneva (CH)
- Centre d'Imagerie BioMedicale (CH)
Publication Details
- Journal
- Journal of Clinical Neurophysiology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1097/wnp.0000000000001141
- Citations
- 1
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 2.25
Funders
- National Science Foundation
- Teva Pharmaceutical Industries
- American Clinical Neurophysiology Society
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- H. Lundbeck A/S